DIRECTOR, PRECISION MEDICINE

At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned.

POSITION SUMMARY:

Day One Biopharmaceuticals is seeking a creative, intelligent, deeply committed, high-integrity, scientific leader to develop and maintain precision medicine vision and strategy and provide expertise in clinical diagnostics across our portfolio of targeted therapeutics for children and adults with cancer. In conjunction with senior leaders in Clinical Development, Translational and Precision Medicine, Regulatory Sciences and supported by a deeply experienced cross-functional team of experts in drug development, you will be responsible for ensuring the consistent application of precision medicine and diagnostics across all stages of clinical development. This individual will be a key member of the Translational and Precision Medicine Team within our Research and Development organization and will report to our Head of Precision Medicine. This role is expected to be a precision medicine functional lead on product teams with influence across all programs, though initially operating as a hands-on individual contributor.

This position has the potential to be fully remote. Occasional travel will be required for in-person meetings.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Develop and maintain precision medicine vision and strategy through cross-functional partnership with Leadership of Clinical Development, Translational Research, Regulatory Sciences, Clinical Pharmacology, and Commercial, as well as other Day One functions
• Design and implement hypothesis-driven strategies to deliver evidence of target engagement, mechanisms of action/resistance, patient selection/CDx strategies and other clinically-relevant biomarker endpoints to advance the Day One pipeline
• Provide technical, clinical and regulatory expertise in assay development and diagnostics (NGS, IHC, Immunoassays along with emerging biomarker technologies and platforms) across diverse stakeholders comprising leadership in Research and Development, Commercial, Regulatory Sciences, Medical Affairs, and Patient Advocacy, including but not limited to, training, education, and representation on behalf of our Translational and Precision Medicine-related events
• Effectively partner with Precision Medicine leaders to execute on the development of clinical biomarkers, assay development through companion diagnostics to maximize patient access to Day One drugs
• Manage external diagnostic partners, CROs, academic collaborators, and vendors to ensure high-quality biomarker and CDx deliverables.
• Leadership expertise in developing and maintaining precision medicine screening strategies across clinical programs, leveraging your extensive experience in testing report interpretation
• Author and review Precision Medicine related publications as well as appropriate sections in clinical study / regulatory documents (i.e. INDs, IBs, trial protocols/ops manuals, ICFs, IRB responses, HA Briefing Books, CSRs, etc.)
• Work closely with Business Development and Precision Medicine leaders to support candidate asset acquisition assessments through clinical biomarker and CDx considerations
• Develop and implement comprehensive clinical biomarker strategy across clinical programs
• Lead the strategic planning and execution of CDx development, including assay selection, analytical validation strategies, clinical validation plans, and alignment with regulatory and commercial partners.
• Help Day One remain a leader in oncology drug development across all ages
• Engaging, inspiring, and successfully communicating with employees of any level in the organization.
• Understanding and embracing one of our highest values: that the most precious asset is our team.
• Proactively contributing to company-building and process evolution as we grow

QUALIFICATIONS

• Bachelor’s degree (PhD or MD/PhD preferred) in biology, immunology, chemistry, pharmacology, biochemistry, or related discipline
• 10+ years’ experience in commercial diagnostic testing and/or oncology drug discovery/development setting within the biopharmaceutical industry (biotech or large pharma).
• A diverse background across assay, diagnostics, cancer biology, and drug development is required with relevant expertise in the interpretation of clinical molecular diagnostic testing reports, and understanding of clinical biomarkers and Companion Diagnostics development strategy and execution is strongly desired
• Pediatric oncology and/or rare disease experiences are highly desirable,
• Ability to interpret complex molecular and clinical datasets and translate insights into program strategy
• Unwavering integrity and trustworthiness, embodying Day One’s core values
• Eloquent and passionate when talking about science and the potential to help patients
• Keen scientific acumen and intellectual curiosity, good judgement, and the highest scientific integrity
• Curious, creative with an ability to think outside of traditional drug development and corporate models
• A team player and a mentor – someone who cares for their colleagues as people as well as contributors and collaborators, while delivering results
• Inspires the confidence of others, and inspires others to fulfill their potential
• The ability to elicit and synthesize information from a range of individuals and sources rapidly and clearly communicate findings across the organization
• Start-up/small biotech experience is strongly preferred or a clear desire to dive into working with a small team.

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.

INTERVIEW INTEGRITY

At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone.

COMPENSATION AND BENEFITS

The salary range for this position is $215,000 - $230,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary.

Please visit https://www.dayonebio.com/benefits to see our competitive benefits.

DISCLAIMER

Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law.

We are unable to sponsor or take over sponsorship of any applicant work visas at this time.

Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.