DIRECTOR, CLINICAL PHARMACOLOGY

At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned.

POSITION SUMMARY:

Day One Biopharmaceuticals is seeking a Director of Clinical Pharmacology to lead and drive early-stage clinical programs. This is a high-impact, hands-on role that requires deep scientific expertise, a rigorous understanding of antibody drug conjugates (ADC), and a proactive, solution-oriented mindset. This position reports to Vice President, Clinical Pharmacology.

The successful candidate will serve as the Clinical Pharmacology Lead and subject matter expert (SME) for one or more ADC programs, playing a critical role in dose selection, optimization, and the integration of pharmacologic and clinical insights. This role is ideal for someone who thrives in the details— taking full ownership of data analysis and interpretation —and is motivated to make a meaningful impact on program direction and success.

This is not a purely strategic leadership role; it requires active, hands-on involvement in all aspects of clinical pharmacology planning and execution. Success in this role depends on deep familiarity with program data, scientific rigor, and a clear understanding of clinical development priorities.

In addition to technical excellence, the ideal candidate will bring a collaborative mindset, accountability, dependability and a strong commitment to high-quality work. The Clinical Pharmacology team and our cross-functional partners foster a culture rooted in trust, open communication, and mutual respect—where team members feel safe speaking up, sharing ideas, and working through challenges together. We take pride in what we do, enjoy our work, and find genuine satisfaction in contributing to the goal of helping patients. This is a team of highly skilled, collaborative, and committed individuals who consistently deliver results, support one another, and thrive in an environment where shared purpose and trust create a naturally positive and cohesive dynamic.

This position has the potential to be fully remote with a preference for Boston or the San Francisco Bay Area. Occasional travel will be required for in-person meetings.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Serve as the Clin Pharm lead for one or more ADC programs within cross-functional team:
  • Lead dose selection and optimization in support of early-stage clinical development and decision-making; you are expected to be SME on dose selection and optimization
  • Provide clear and actionable recommendations to the cross-functional team by review, analysis, and interpretation of PK, PD, and exposure-response data; you are expected to be the primary expert on your data and prepared to discuss it confidently and accurately at any time
  • Drive clinical pharmacology strategy and execution with direct accountability for data integrity and scientific interpretation
  • Translate cross-functional questions into clear, actionable Clin Pharm objectives with defined scopes of work and timelines
  • Author and maintain a comprehensive Clinical Pharmacology Plan, ensuring timely execution of deliverables
  • Author or co-author, and critically review key program documents including Investigator’s brochure, clinical trial protocols, study reports, and regulatory submission documents.
  • Collaborate with Medical Affairs to support scientific communications, including abstracts, posters, and manuscripts for conferences and peer-reviewed publications
  • Respond to clinical pharmacology-related inquiries from medical monitors, investigators, and cross-functional stakeholders
  • Lead clinical pharmacology input and strategy for regulatory interactions, including written responses and meetings with Health Authority
  • Oversee external vendors: monitor vendor performance to ensure alignment with scientific and operational expectations and provide timely, constructive feedback to support high-quality deliverables and effective collaboration

• May serve as a strategic leader for the clinical program:
  • Identify and proactively resolve issues that may impact the programs execution (e.g., data quality or timelines)
  • Influence program direction using integrated scientific, clinical, and business insights
  • Provide leadership and mentorship to junior colleagues or contractors, including effective delegation, professional development, and performance support

QUALIFICATIONS

• PhD, PharmD, or equivalent in pharmaceutical sciences, clinical pharmacology, pharmacokinetics, or related discipline.
• 10+ years of industry experience in clinical pharmacology, with a strong preference for hands-on experience in ADC program
• Proven ability to lead in a fast-paced, cross-functional, and collaborative environment.
• Strong written and verbal communication skills, with the ability to clearly convey complex scientific and clinical concepts to diverse audiences.
• Demonstrated strategic thinking coupled with strong attention to detail and operational execution

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.

INTERVIEW INTEGRITY

At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone.

COMPENSATION AND BENEFITS

The salary range for this position is $220,000-$240,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary.

Please visit https://www.dayonebio.com/benefits to see our competitive benefits.

DISCLAIMER

Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law.

We are unable to sponsor or take over sponsorship of any applicant work visas at this time.

Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.